https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Locus for severity implicates CNS resilience in progression of multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52436 Wed 11 Oct 2023 14:54:40 AEDT ]]> Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46138 Tue 04 Apr 2023 18:59:19 AEST ]]> A pharmacogenetic study implicates NINJ2 in the response to Interferon-ß in multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38338 -4, hazard ratio = 1.41). Moreover, rs7298096AA is associated with a higher NINJ2 expression in blood (p = 7.0 x 10-6), which was confirmed in vitro (p = 0.009). Finally, NINJ2 expression is downregulated by IFNβ treatment and related to TTFR. Conclusions: Rs7298096 could influence MS disease activity during IFNβ treatment by modulating NINJ2 expression in blood. The gene encodes for an adhesion molecule involved in inflammation and endothelial cells activation, supporting its role in MS.]]> Mon 30 Aug 2021 13:46:38 AEST ]]>